Butyrylcholinesterase in UV Reactions

The authors analyzed butyrylcholinesterase status in melanocytic pathology and possible association of enzyme activity with melanoma diagnose and progression. Butyrylcholinesterase activity showed no changes between melanoma and dysplastic nevi, between melanoma and control, between nevi and control, but it had a statistically significant variation between primary and metastatic melanoma. Butyrylcholinesterase activity had statistically significant variations with site of tumor (p=0.001), with histological type (p=0.0017), with Clark level (p=0.007) and with the presence/absence of ulceration (p=0.004). We analyzed the variations of butyrylcholinesterase activity by markers for melanoma staging and progression in primary and metastatic melanoma. Significant correlations were recorded between butyrylcholinesterase and melanoma progression. The authors obtained a negative correlation between butyrylcholinesterase activity and CRP, between butyrylcholinesterase and malondialdehyde. A positive correlation was observed between butyrylcholinesterase and albumin in patients with metastatic melanoma.